The risk of toxicidade of the acid folic is low; therefore the folate is a soluble vitamin in water and regularly is removed of the body through piss. The Institute of Medicine established a level of tolerable ingestion (UL) for 1 mg of acid folic for adult men and women, and 800 UL of mg for gestates and suckling babies (breast-feeding) women with less than 18 years of age. Supplemental of acid folic the UL does not have to exceed to prevent the acid folic to mask symptoms of deficiency B12 vitamin.
The research suggests high levels of acid folic can intervene with some treatments against the malaria.
A study carried through with 10.000 patients in the Tufts University, in 2007 it concluded the acid folic in excess aggravates the effect of deficiency B12 the vitamin and, in fact, it can affect absorption B12 the vitamin.
A study of the University of Adelaide, it concluded the ingestion of supplements of acid folic during the delayed pregnancy increases the risk of babies in development of the infantile asthma in 30%, the researchers had even so emphasized that its discoveries do not contradict the recommendations of supplement of acid folic in the first trimester, when does not have more risk was found.
Aged population
Has advantages and risks of foods the blockhouse with acid folic for the aged population. Raised of exposition to the acid folic, due to blockhouse it can improve the levels of folate and homocysteine, but it can also mask symptoms of deficiency B12 vitamin. A study in 747 individuals with ages between 67-96 statuses of homocysteine had been years measured for vitamin B eon had presented diets with addition of acid folic of 140μg/100 g of product of grains diminished the level of homocysteine eo risk of cardiac illnesses. However, it offers of food of Canada is strengthened with 150 μg/100 g of grains, and great part of the aged population also has a supplement that it includes a component of acid 400 folic of mcg. Therefore, it is important not to consume amounts recommended for the DRI.