The acid folic is an important nutrient for the women who can engraved, because the levels of a woman of blood of the fall of folate during the pregnancy due to an increase of maternal synthesis RBC in the first half of the pregnancy and demand fetal in as the semester. The four first weeks of pregnancy (when the majority of the women not even perceive that they are pregnant) demand the acid folic for the adequate development of the brain, skull and spinal marrow. Serious congenital defects, as defects of the neural pipe are less probable to occur when the 0.4 women take mg of acid folic daily. The adequate ingestion of acid folic during the period daily pay-conception, the time immediately before and immediately after the woman engraved, helps to protect against a series of congenital malformations, including the defects of the neural pipe (that more notables are the birth defects who occur for folate deficiency). Defects of the neural pipe (DTN) to result in malformations of the vertebral column (bifid spine), skull and brain (anencephaly). The risk of defects of the neural pipe significantly is reduced when the acid supplemental folic is consumed, beyond a healthful diet before and during the first month after the conception. The protective effect of the acid folic during the pregnancy goes beyond the DTN. The supplementation with acid folic has been shown to reduce the risk of congenital cardiac defects, leporine lip, defects in the members, and anomalies of the urinary treatment. Women who could engraved are advised to eat foods enriched with acid folic or to take supplements stops beyond eating rich foods in folate to reduce the risk of some serious congenital defects. Having in supplements of acid enough folic in the months before the pregnancy it is very important to prevent defects of the neural pipe. To take 400 micrograms of acid daily synthetic folic of fortified foods and/or supplements has been suggested. The RDA for the folate equivalents for pregnant women is 600-800 microgram, two times the normal RDA of 400 micrograms for women who are not pregnant.
A study published for the Milunski et al. it has women had indicated that they take supplements of acid folic during the pregnancy can drastically reduce the prevalence of defects of the infantile neural pipe in 74%, 3.5-0.9 defects for 1000 births.
Although the ingestion of acid folic recommended for women who plan for the pregnancy is of 400 micrograms per day, the mechanisms and the reasons for which the acid folic prevents birth defects are unknown