Other mechanisms have been proposed to explain the utility of training in altitude. All the studies do not show a statistically significant increase in red globules of training in altitude. A study explains the success by means of the increase of the intensity of the formation (due to cardiac it increased and the rate of breathing). This improvement of the formation as resulting from the effects that lasted more than 15 days after the return at the level of the sea.
Another group of investigators affirms that the training in altitude stimulates a more efficient use of oxygen by the efficiency muscles. This can arise from many other answers to the altitude formation, including the angiogenesis, the glucose transport, the glycolysis and the regulation of pH, each one of them could explain the improvement partly the independent endurance of a greater number of red globules cells. Furthermore, to make exercise to high altitude has demonstrated that it causes muscular adaptations of the transcriptions of the selected gene, and the improvement of the properties of mitochondria in the skeletal muscle.
In a study that compared the rats that work to high altitude in comparison with the rats that work at level of the sea, with two sedentary groups control, it was observed that the types of muscular fibers change according to the challenges homeostatic that beta gave rise to an increase of the metabolic efficiency during the cycle oxidation and the cycle of citric acid, showing a greater use of ATP for the aerobic yield.